4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans

In bacteria, DNA methylation can be facilitated by ‘orphan’ DNA methyltransferases lacking cognate restriction endonucleases, but whether and how these enzymes control key cellular processes are poorly understood. The effects of a specific modification, 4-methylcytosine (4mC), are even less clear, a...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Gaultney, Robert A, Vincent, Antony T, Lorioux, Céline, Coppée, Jean-Yves, Sismeiro, Odile, Varet, Hugo, Legendre, Rachel, Cockram, Charlotte A, Veyrier, Frédéric J, Picardeau, Mathieu
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708080/
https://ncbi.nlm.nih.gov/pubmed/33301041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa966
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