4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans

In bacteria, DNA methylation can be facilitated by ‘orphan’ DNA methyltransferases lacking cognate restriction endonucleases, but whether and how these enzymes control key cellular processes are poorly understood. The effects of a specific modification, 4-methylcytosine (4mC), are even less clear, a...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Gaultney, Robert A, Vincent, Antony T, Lorioux, Céline, Coppée, Jean-Yves, Sismeiro, Odile, Varet, Hugo, Legendre, Rachel, Cockram, Charlotte A, Veyrier, Frédéric J, Picardeau, Mathieu
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708080/
https://ncbi.nlm.nih.gov/pubmed/33301041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa966
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