The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination

Meiotic recombination enables reciprocal exchange of genetic information between parental chromosomes and is essential for fertility. MEIOB, a meiosis-specific ssDNA-binding protein, regulates early meiotic recombination. Here we report that the human infertility-associated missense mutation (N64I)...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Guo, Rui, Xu, Yang, Leu, N Adrian, Zhang, Lei, Fuchs, Serge Y, Ye, Lan, Wang, P Jeremy
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708077/
https://ncbi.nlm.nih.gov/pubmed/33166385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1016
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