Deletion of Akt1 Promotes Kidney Fibrosis in a Murine Model of Unilateral Ureteral Obstruction

We investigated the role of Akt1, one of the three isoforms of Akt, in renal fibrosis using the murine model of unilateral ureteral obstruction (UUO). We subjected wild type and Akt1(−/−) mice to UUO. The Akt1 gene was silenced in vitro using short hairpin RNA delivered via a lentiviral vector in hu...

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Bibliographic Details
Published in:Biomed Res Int
Main Authors: Kim, Il Young, Lee, Min Young, Park, Mi Wha, Seong, Eun Young, Lee, Dong Won, Lee, Soo Bong, Bae, Sun Sik, Kim, Sang Soo, Song, Sang Heon
Format: Artigo
Language:Inglês
Published: Hindawi 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707954/
https://ncbi.nlm.nih.gov/pubmed/33299873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/6143542
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