Deletion of Akt1 Promotes Kidney Fibrosis in a Murine Model of Unilateral Ureteral Obstruction

We investigated the role of Akt1, one of the three isoforms of Akt, in renal fibrosis using the murine model of unilateral ureteral obstruction (UUO). We subjected wild type and Akt1(−/−) mice to UUO. The Akt1 gene was silenced in vitro using short hairpin RNA delivered via a lentiviral vector in hu...

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Detalles Bibliográficos
Publicado en:Biomed Res Int
Main Authors: Kim, Il Young, Lee, Min Young, Park, Mi Wha, Seong, Eun Young, Lee, Dong Won, Lee, Soo Bong, Bae, Sun Sik, Kim, Sang Soo, Song, Sang Heon
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707954/
https://ncbi.nlm.nih.gov/pubmed/33299873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/6143542
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