DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity

Deciphering the mechanisms that regulate the sensitivity of pathogen recognition receptors is imperative to understanding infection and inflammation. Here we demonstrate that the RNA triphosphatase dual-specificity phosphatase 11 (DUSP11) acts on both host and virus-derived 5′-triphosphate RNAs rend...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Choi, Joon H., Burke, James M., Szymanik, Kayla H., Nepal, Upasana, Battenhouse, Anna, Lau, Justin T., Stark, Aaron, Lam, Victor, Sullivan, Christopher S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706711/
https://ncbi.nlm.nih.gov/pubmed/33184222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340604.120
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