A six-amino-acid motif is a major determinant in functional evolution of HOX1 proteins

Gene duplication and divergence is a major driver in the emergence of evolutionary novelties. How variations in amino acid sequences lead to loss of ancestral activity and functional diversification of proteins is poorly understood. We used cross-species functional analysis of Drosophila Labial and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Singh, Narendra Pratap, De Kumar, Bony, Paulson, Ariel, Parrish, Mark E., Zhang, Ying, Florens, Laurence, Conaway, Joan W., Si, Kausik, Krumlauf, Robb
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706710/
https://ncbi.nlm.nih.gov/pubmed/33184220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.342329.120
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