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Heparanase and the hallmarks of cancer
Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to heparan sulphate. This in turn promotes both physiological and...
Gardado en:
| Publicado en: | J Transl Med |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7706218/ https://ncbi.nlm.nih.gov/pubmed/33256730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02624-1 |
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