An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

Soluble forms of angiotensin-converting enzyme 2 (ACE2) have recently been shown to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We report on an improved soluble ACE2, termed a “microbody,” in which the ACE2 ectodomain is fused to Fc domain 3 of the immunoglobulin...

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Vydáno v:Cell Rep
Hlavní autoři: Tada, Takuya, Fan, Chen, Chen, Jennifer S., Kaur, Ramanjit, Stapleford, Kenneth A., Gristick, Harry, Dcosta, Belinda M., Wilen, Craig B., Nimigean, Crina M., Landau, Nathaniel R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Authors. 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705358/
https://ncbi.nlm.nih.gov/pubmed/33326798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108528
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