Mutant thermal proteome profiling for characterization of missense protein variants and their associated phenotypes within the proteome

Temperature-sensitive (TS) missense mutants have been foundational for characterization of essential gene function. However, an unbiased approach for analysis of biochemical and biophysical changes in TS missense mutants within the context of their functional proteomes is lacking. We applied MS-base...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Peck Justice, Sarah A., Barron, Monica P., Qi, Guihong D., Wijeratne, H. R. Sagara, Victorino, José F., Simpson, Ed R., Vilseck, Jonah Z., Wijeratne, Aruna B., Mosley, Amber L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Genomics and Proteomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705321/
https://ncbi.nlm.nih.gov/pubmed/32878984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014576
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