Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2

The melanocortin receptor accessory protein 2 (MRAP2) plays a pivotal role in the regulation of several G protein–coupled receptors that are essential for energy balance and food intake. MRAP2 loss-of-function results in obesity in mammals. MRAP2 and its homolog MRAP1 have an unusual membrane topolo...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Chen, Valerie, Bruno, Antonio E., Britt, Laura L., Hernandez, Ciria C., Gimenez, Luis E., Peisley, Alys, Cone, Roger D., Millhauser, Glenn L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705299/
https://ncbi.nlm.nih.gov/pubmed/32943551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015482
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