Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Negative allosteric modulation of the metabotropic glutamate 5 (mGlu(5)) receptor has emerged as a potential strategy for the treatment of neurologic disorders. Despite the success in preclinical studies, many mGlu(5) negative allosteric modulators (NAMs) that have reached clinical trials failed due...

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Publicat a:Mol Pharmacol
Autors principals: Arsova, Angela, Møller, Thor C., Vedel, Line, Hansen, Jakob Lerche, Foster, Simon R., Gregory, Karen J., Bräuner-Osborne, Hans
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705108/
https://ncbi.nlm.nih.gov/pubmed/32358164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.119032
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