Vesicular Stomatitis Virus Encoding a Destabilized Tumor Antigen Improves Activation of Anti-tumor T Cell Responses

Enhancing the immunogenicity of tumor-associated antigens would represent a major advance for anti-tumor vaccination strategies. Here, we investigated structure-directed antigen destabilization as a strategy to improve the degradation, immunogenic epitope presentation, and T cell activation against...

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Vydáno v:Mol Ther
Hlavní autoři: Huff, Amanda L., Evgin, Laura, Thompson, Jill, Kottke, Tim, Driscoll, Christopher B., Tonne, Jason, Wongthida, Phonphimon, Schuelke, Matthew, Shim, Kevin G., Mer, Georges, Ramirez-Alvarado, Marina, Vile, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705043/
https://ncbi.nlm.nih.gov/pubmed/32877695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.08.013
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