Structural characterization of a dimeric complex between the short cytoplasmic domain of CEACAM1 and the pseudo tetramer of S100A10-Annexin A2 using NMR and molecular dynamics

AIIt, a heterotetramer of S100A10 (P11) and Annexin A2, plays a key role in calcium dependent, membrane associations with a variety of proteins. We previously showed that AIIt interacts with the short cytoplasmic domain (12 amino acids) of CEACAM1 (CEACAM1-SF). Since the cytoplasmic domains of CEACA...

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Veröffentlicht in:Biochim Biophys Acta Biomembr
Hauptverfasser: Hu, Weidong, Bhattacharya, Supriyo, Hong, Teresa, Wong, Patty, Li, Lin, Vaidehi, Nagarajan, Kalkum, Markus, Shively, John E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704867/
https://ncbi.nlm.nih.gov/pubmed/32835655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2020.183451
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