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Altered Redox Regulation and S-Glutathionylation of BiP Contribute to Bortezomib Resistance in Multiple Myeloma.
Multiple myeloma (MM) cells have high rates of secretion of proteins rich in disulfide bonds and depend upon compartmentalized redox balance for accurate protein folding. The proteasome inhibitor bortezomib (Btz) is a successful frontline treatment for the disease, but its long-term efficacy is rest...
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| Pubblicato in: | Free Radic Biol Med |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7704679/ https://ncbi.nlm.nih.gov/pubmed/32937189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.09.013 |
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