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4-Hydroxy-7-oxo-5-heptenoic acid lactone can induce mitochondrial dysfunction in retinal pigmented epithelial cells

Oxidation of docosahexaenoate (DHA)-containing phospholipids in the cell plasma membrane leads to release of the α,β-unsaturated aldehyde 4-hydroxy-7-oxo-5-heptenoic acid (HOHA) lactone which is capable of inducing retinal pigmented epithelial (RPE) cell dysfunction. Previously, HOHA lactone was sho...

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Detalles Bibliográficos
Publicado en:Free Radic Biol Med
Main Authors: Cheng, Yu-Shiuan, Linetsky, Mikhail, Li, Haoting, Ayyash, Naji, Gardella, Anthony, Salomon, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704664/
https://ncbi.nlm.nih.gov/pubmed/32920040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.09.009
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