4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells

We previously discovered that oxidative cleavage of docosahexaenoate (DHA), which is especially abundant in the retinal photoreceptor rod outer segments and retinal pigmented endothelial (RPE) cells, generates 4-hydroxy-7-oxo-5-heptenoate (HOHA) lactone, and that HOHA lactone can enter RPE cells tha...

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Publicado no:Chem Res Toxicol
Main Authors: Linetsky, Mikhail, Bondelid, Karina S., Losovskiy, Sofiya, Gabyak, Vadym, Rullo, Mario J., Stiadle, Thomas I., Munjapara, Vasu, Saxena, Priyali, Ma, Duoming, Cheng, Yu-Shiuan, Howes, Andrew M., Udeigwe, Emeka, Salomon, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102073/
https://ncbi.nlm.nih.gov/pubmed/29883119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00028
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