Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGF-β Signaling

RING-finger E3 ligases are instrumental in the regulation of inflammatory cascades, apoptosis, and cancer. However, their roles are relatively unknown in TGF-β/SMAD signaling. SMAD3 and its adaptors, such as β2SP, are important mediators of TGF-β signaling and regulate gene expression to suppress st...

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Vydáno v:Cancer Res
Hlavní autoři: Chen, Jian, Mitra, Abhisek, Li, Shulin, Song, Shumei, Nguyen, Bao-Ngoc, Chen, Jiun-Sheng, Shin, Ji-hyun, Gough, Nancy R., Lin, Paul, Obias, Vincent, He, Aiwu Ruth, Yao, Zhixing, Malta, Tathiane M, Noushmehr, Houtan, Latham, Patricia S., Su, Xiaoping, Rashid, Asif, Mishra, Bibhuti, Wu, Ray-Chang, Mishra, Lopa
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704101/
https://ncbi.nlm.nih.gov/pubmed/32127355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3116
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