Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia

In several neurodegenerative disorders, axonal pathology may originate from impaired oligodendrocyte-to-axon support of energy substrates. We previously established transgenic mice that allow measuring axonal ATP levels in electrically active optic nerves. Here, we utilize this technique to explore...

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Udgivet i:PLoS Biol
Main Authors: Trevisiol, Andrea, Kusch, Kathrin, Steyer, Anna M., Gregor, Ingo, Nardis, Christos, Winkler, Ulrike, Köhler, Susanne, Restrepo, Alejandro, Möbius, Wiebke, Werner, Hauke B., Nave, Klaus-Armin, Hirrlinger, Johannes
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704050/
https://ncbi.nlm.nih.gov/pubmed/33196637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000943
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