Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia

In several neurodegenerative disorders, axonal pathology may originate from impaired oligodendrocyte-to-axon support of energy substrates. We previously established transgenic mice that allow measuring axonal ATP levels in electrically active optic nerves. Here, we utilize this technique to explore...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS Biol
Κύριοι συγγραφείς: Trevisiol, Andrea, Kusch, Kathrin, Steyer, Anna M., Gregor, Ingo, Nardis, Christos, Winkler, Ulrike, Köhler, Susanne, Restrepo, Alejandro, Möbius, Wiebke, Werner, Hauke B., Nave, Klaus-Armin, Hirrlinger, Johannes
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2020
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704050/
https://ncbi.nlm.nih.gov/pubmed/33196637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000943
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