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Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies
Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes. Although wild-type full-length NUP98 is a member of the nuclear pore complex, the chromosomal translocations leading to NUP98 gene fusions i...
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| Veröffentlicht in: | Blood |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7702474/ https://ncbi.nlm.nih.gov/pubmed/32766874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007093 |
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