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Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies

Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes. Although wild-type full-length NUP98 is a member of the nuclear pore complex, the chromosomal translocations leading to NUP98 gene fusions i...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Michmerhuizen, Nicole L., Klco, Jeffery M., Mullighan, Charles G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702474/
https://ncbi.nlm.nih.gov/pubmed/32766874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007093
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