Fragment-derived modulators of an industrial β-glucosidase

A fragment screen of a library of 560 commercially available fragments using a kinetic assay identified a small molecule that increased the activity of the fungal glycoside hydrolase TrBgl2. An analogue by catalogue approach and detailed kinetic analysis identified improved compounds that behaved as...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Makraki, Eleni, Darby, John F., Carneiro, Marta G., Firth, James D., Heyam, Alex, Ab, Eiso, O'Brien, Peter, Siegal, Gregg, Hubbard, Roderick E.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702302/
https://ncbi.nlm.nih.gov/pubmed/33111951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200507
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