The Dimeric Form of 1,3‐Diaminoisoquinoline Derivative Rescued the Mis‐splicing of Atp2a1 and Clcn1 Genes in Myotonic Dystrophy Type 1 Mouse Model

Expanded CUG repeat RNA in the dystrophia myotonia protein kinase (DMPK) gene causes myotonic dystrophy type 1 (DM1) and sequesters RNA processing proteins, such as the splicing factor muscleblind‐like 1 protein (MBNL1). Sequestration of splicing factors results in the mis‐splicing of some pre‐mRNAs...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Matsumoto, Jun, Nakamori, Masayuki, Okamoto, Tatsumasa, Murata, Asako, Dohno, Chikara, Nakatani, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702137/
https://ncbi.nlm.nih.gov/pubmed/32449537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001572
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