Neutrophil Elastase Facilitates Tumor Cell Intravasation and Early Metastatic Events

Functional roles of neutrophil elastase (NE) have not been examined in distinct steps of the metastatic cascade. NE, delivered to primary tumors as a purified enzyme or within intact neutrophils or neutrophil granule content, enhanced human tumor cell intravasation and subsequent dissemination via N...

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Veröffentlicht in:iScience
Hauptverfasser: Deryugina, Elena, Carré, Alexia, Ardi, Veronica, Muramatsu, Tomoki, Schmidt, Jonas, Pham, Christine, Quigley, James P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702017/
https://ncbi.nlm.nih.gov/pubmed/33299970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101799
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