Loss of DEK Expression Induces Alzheimer’s Disease Phenotypes in Differentiated SH-SY5Y Cells

Alzheimer’s disease (AD) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary Tau tangles. This leads to decreased synaptic efficacy, cell death, and, consequently, brain atrophy in patients. Behaviorally, this manifests as memory loss and...

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Опубликовано в: :Front Mol Neurosci
Главные авторы: Greene, Allie N., Parks, Lois G., Solomon, Matia B., Privette Vinnedge, Lisa M.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7701170/
https://ncbi.nlm.nih.gov/pubmed/33304240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.594319
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