Design, Synthesis, and Antitumor Activity of a Series of Novel 4-(Aromatic Sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-ones

Many sulfonamides show anticancer activity. Based on benzenesulfonylazaspirodienone (HL-X9) identified in our previous work, we optimized the lead compound for better efficacy, thereby synthesizing a series of novel 4-(aromatic sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-one derivatives through a...

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Vydáno v:Molecules
Hlavní autoři: Xing, Naiguo, Chen, Chen, Zhong, Qiu, Zheng, Shilong, Wang, Guangdi, He, Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700525/
https://ncbi.nlm.nih.gov/pubmed/33233396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25225459
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