Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC

SIMPLE SUMMARY: Here, we demonstrate that the hypoxia-induced cleaved form of VDAC1 (VDAC1-ΔC) reprograms the cell to utilize more metabolites and is implicated in up-regulation of glycolysis and mitochondrial respiration, conferring a direct survival advantage in hypoxic microenvironment. We furthe...

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Publicat a:Cancers (Basel)
Autors principals: Meyenberg Cunha-de Padua, Monique, Fabbri, Lucilla, Dufies, Maeva, Lacas-Gervais, Sandra, Contenti, Julie, Voyton, Charles, Fazio, Sofia, Irondelle, Marie, Mograbi, Baharia, Rouleau, Matthieu, Sadaghianloo, Nirvana, Rovini, Amandine, Brenner, Catherine, Craigen, William J., Bourgeais, Jérôme, Herault, Olivier, Bost, Frédéric, Mazure, Nathalie M.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700438/
https://ncbi.nlm.nih.gov/pubmed/33238609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12113484
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