Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences

Novel antibiotics are urgently needed to address the looming global crisis of antibiotic resistance. Historically, the primary source of clinically used antibiotics has been microbial secondary metabolism. Microbial genome sequencing has revealed a plethora of uncharacterized natural antibiotics tha...

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Publicat a:Nat Commun
Autors principals: Skinnider, Michael A., Johnston, Chad W., Gunabalasingam, Mathusan, Merwin, Nishanth J., Kieliszek, Agata M., MacLellan, Robyn J., Li, Haoxin, Ranieri, Michael R. M., Webster, Andrew L. H., Cao, My P. T., Pfeifle, Annabelle, Spencer, Norman, To, Q. Huy, Wallace, Dan Peter, Dejong, Chris A., Magarvey, Nathan A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699628/
https://ncbi.nlm.nih.gov/pubmed/33247171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19986-1
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