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GEN-14 Dual regulation of histone methylation by mTOR complexes drives the progression of EGFR-mutant glioblastoma

Trimethylation of histone H3 on lysine 27 (H3K27me3) is essential for ensuring proper gene expression and chromosomal function, and its aberration is associated with the pathogenesis of various brain tumors. However, it remains unclear how histone methylation is regulated in response to genetic muta...

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Bibliografiske detaljer
Udgivet i:Neurooncol Adv
Main Authors: Masui, Kenta, Harachi, Mio, Muragaki, Yoshihiro, Mischel, Paul, Shibata, Noriyuki
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699103/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa143.022
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