Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

The serine/threonine kinase, GSK-3, is a promising drug discovery target for treating multiple pathological disorders. Most GSK-3 inhibitors that were developed function as ATP competitive inhibitors, with typical limitations in specificity, safety and drug-induced resistance. In contrast, substrate...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Rippin, Ido, Khazanov, Netaly, Ben Joseph, Shirley, Kudinov, Tania, Berent, Eva, Arciniegas Ruiz, Sara Melisa, Marciano, Daniele, Levy, Laura, Gruzman, Arie, Senderowitz, Hanoch, Eldar-Finkelman, Hagit
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7698860/
https://ncbi.nlm.nih.gov/pubmed/33218072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228709
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