Tumor Necrosis Factor Receptor-1 (p55) Deficiency Attenuates Tumor Growth and Intratumoral Angiogenesis and Stimulates CD8(+) T Cell Function in Melanoma

The role of tumor necrosis factor-α (TNF-α) in shaping the tumor microenvironment is ambiguous. Consistent with its uncertain role in melanoma, TNF-α plays a dual role, either acting as a cytotoxic cytokine or favoring a tumorigenic inflammatory microenvironment. TNF-α signals via two cognate recept...

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Udgivet i:Cells
Main Authors: Rodriguez, Yamila I., Campos, Ludmila E., Castro, Melina G., Bannoud, Nadia, Blidner, Ada G., Filippa, Verónica P., Croci, Diego O., Rabinovich, Gabriel A., Alvarez, Sergio E.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696624/
https://ncbi.nlm.nih.gov/pubmed/33202705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9112469
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