Bi-Functional Alginate Oligosaccharide–Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections

The recent emergence of resistance to colistin, an antibiotic of last resort with dose-limiting toxicity, has highlighted the need for alternative approaches to combat infection. This study aimed to generate and characterise alginate oligosaccharide (“OligoG”)–polymyxin (polymyxin B and E (colistin)...

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Publicado en:Pharmaceutics
Main Authors: Stokniene, Joana, Powell, Lydia C., Aarstad, Olav A., Aachmann, Finn L., Rye, Philip D., Hill, Katja E., Thomas, David W., Ferguson, Elaine L.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696216/
https://ncbi.nlm.nih.gov/pubmed/33187332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12111080
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