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Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies

Thymidylate synthase (TS) has emerged as a hot spot in cancer treatment, as it is directly involved in DNA synthesis. In the present article, nine hybrids containing 1,2,3-triazole and 1,3,4-oxadiazole moieties (6–14) were synthesized and evaluated for anticancer and in vitro thymidylate synthase ac...

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Dettagli Bibliografici
Pubblicato in:Pharmaceuticals (Basel)
Autori principali: Alam, Mohammad Mahboob, Almalki, Abdulraheem SA, Neamatallah, Thikryat, Ali, Nada M., Malebari, Azizah M., Nazreen, Syed
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696185/
https://ncbi.nlm.nih.gov/pubmed/33202652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13110390
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