PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity

Human carbonic anhydrase IX (CAIX), a unique member of the α carbonic anhydrase family, is a transmembrane glycoprotein with high enzymatic activity by which CAIX contributes to tumorigenesis through pH regulation. Due to its aberrant expression, CAIX is considered to be a marker of tumor hypoxia an...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Simko, Veronika, Belvoncikova, Petra, Csaderova, Lucia, Labudova, Martina, Grossmannova, Katarina, Zatovicova, Miriam, Kajanova, Ivana, Skultety, Ludovit, Barathova, Monika, Pastorek, Jaromir
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696048/
https://ncbi.nlm.nih.gov/pubmed/33198416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228545
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