Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism

Membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14), a transmembrane proteinase with a short cytoplasmic tail, is a major effector of extracellular matrix remodeling. Genetic silencing of MT1-MMP in mouse (Mmp14(−/−)) and man causes dwarfism, osteopenia, arthritis, and lipodystrophy, abnormal...

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Publicado no:iScience
Main Authors: Attur, Mukundan, Lu, Cuijie, Zhang, Xiaodong, Han, Tianzhen, Alexandre, Cassidy, Valacca, Cristina, Zheng, Shuai, Meikle, Sarina, Dabovic, Branka Brukner, Tassone, Evelyne, Yang, Qing, Kolupaeva, Victoria, Yakar, Shoshana, Abramson, Steven, Mignatti, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695985/
https://ncbi.nlm.nih.gov/pubmed/33294797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101789
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