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Promotion of cadmium uptake and cadmium-induced toxicity by the copper transporter CTR1 in HepG2 and ZFL cells

Cadmium (Cd(2+)) is considered a human carcinogen as it causes oxidative stress and alters DNA repair responses. However, how Cd(2+) is taken up by cells remains unclear. We hypothesized that Cd(2+) could be transported into cells via a membrane copper (Cu) transporter, CTR1. CTR1 expression was not...

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Publicado en:Toxicol Rep
Main Authors: Kwok, Man Long, Li, Zhen Ping, Law, Tin Yu Samuel, Chan, King Ming
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695923/
https://ncbi.nlm.nih.gov/pubmed/33294387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2020.11.005
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