Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome

Firre encodes a lncRNA involved in nuclear organization. Here, we show that Firre RNA expressed from the active X chromosome maintains histone H3K27me3 enrichment on the inactive X chromosome (Xi) in somatic cells. This trans-acting effect involves SUZ12, reflecting interactions between Firre RNA an...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Fang, He, Bonora, Giancarlo, Lewandowski, Jordan P., Thakur, Jitendra, Filippova, Galina N., Henikoff, Steven, Shendure, Jay, Duan, Zhijun, Rinn, John L., Deng, Xinxian, Noble, William S., Disteche, Christine M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695720/
https://ncbi.nlm.nih.gov/pubmed/33247132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19879-3
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