CRISPR based editing of SIV proviral DNA in ART treated non-human primates

Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non-human primate model of HIV infection, with adeno-associated virus 9 (AAV9)-CRISPR/Cas9 gene editing construct designed for...

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Publicado en:Nat Commun
Main Authors: Mancuso, Pietro, Chen, Chen, Kaminski, Rafal, Gordon, Jennifer, Liao, Shuren, Robinson, Jake A., Smith, Mandy D., Liu, Hong, Sariyer, Ilker K., Sariyer, Rahsan, Peterson, Tiffany A., Donadoni, Martina, Williams, Jaclyn B., Siddiqui, Summer, Bunnell, Bruce A., Ling, Binhua, MacLean, Andrew G., Burdo, Tricia H., Khalili, Kamel
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695718/
https://ncbi.nlm.nih.gov/pubmed/33247091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19821-7
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