PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes

Major histocompatibility complex (MHC)–unrestricted cytotoxic lymphocytes (CLs) such as natural killer (NK) cells can detect and destroy tumor and virus-infected cells resistant to T cell–mediated killing. Here, we performed genome-wide genetic screens to identify tumor-intrinsic genes regulating ki...

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Publicado en:Sci Adv
Autores principales: Menasche, Bridget L., Davis, Eric M., Wang, Shifeng, Ouyang, Yan, Li, Suzhao, Yu, Haijia, Shen, Jingshi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695474/
https://ncbi.nlm.nih.gov/pubmed/33246952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc3243
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