A facile one-stage treatment of critical bone defects using a calcium sulfate/hydroxyapatite biomaterial providing spatiotemporal delivery of bone morphogenic protein–2 and zoledronic acid

Bone morphogenic proteins (BMPs) are the only true osteoinductive molecules. Despite being tremendously potent, their clinical use has been limited for reasons including supraphysiological doses, suboptimal delivery systems, and the pro-osteoclast effect of BMPs. Efforts to achieve spatially control...

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Publicado en:Sci Adv
Autores principales: Raina, Deepak Bushan, Matuszewski, Lucas-Maximilian, Vater, Corina, Bolte, Julia, Isaksson, Hanna, Lidgren, Lars, Tägil, Magnus, Zwingenberger, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695465/
https://ncbi.nlm.nih.gov/pubmed/33246951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc1779
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