Single-cell transcriptional diversity is a hallmark of developmental potential

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation is challenging. Here, we demonstrate a simple, yet robust, determinant of developmental potential—the number of e...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Gulati, Gunsagar S., Sikandar, Shaheen S., Wesche, Daniel J., Manjunath, Anoop, Bharadwaj, Anjan, Berger, Mark J., Ilagan, Francisco, Kuo, Angera H., Hsieh, Robert W., Cai, Shang, Zabala, Maider, Scheeren, Ferenc A., Lobo, Neethan A., Qian, Dalong, Yu, Feiqiao B., Dirbas, Frederick M., Clarke, Michael F., Newman, Aaron M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694873/
https://ncbi.nlm.nih.gov/pubmed/31974247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax0249
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