Co-Application of Eugenol and QX-314 Elicits the Prolonged Blockade of Voltage-Gated Sodium Channels in Nociceptive Trigeminal Ganglion Neurons

Local anesthetics (LAs) can completely block nociception by inhibiting voltage-gated sodium channels (VGSCs), and thus, blocking action potentials (APs) within sensory neurons. As one of the several LAs, eugenol is used for dental pain treatment. It reportedly features multiple functions in regulati...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Hwang, Sung-Min, Lee, Kihwan, Im, Sang-Taek, Go, Eun Jin, Kim, Yong Ho, Park, Chul-Kyu
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694476/
https://ncbi.nlm.nih.gov/pubmed/33167484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10111513
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