Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability

SIMPLE SUMMARY: Osteolytic bone lesions represent an important clinical feature of multiple myeloma (MM). MM cells metabolize very high amounts of glutamine (Gln) and significantly lower Gln in the bone marrow. In this contribution we demonstrate that MM-dependent Gln depletion impairs the different...

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Publicado no:Cancers (Basel)
Main Authors: Chiu, Martina, Toscani, Denise, Marchica, Valentina, Taurino, Giuseppe, Costa, Federica, Bianchi, Massimiliano G., Andreoli, Roberta, Franceschi, Valentina, Storti, Paola, Burroughs-Garcia, Jessica, Eufemiese, Rosa Alba, Dalla Palma, Benedetta, Campanini, Nicoletta, Martella, Eugenia, Mancini, Cristina, Shan, Jixiu, Kilberg, Michael S., D’Amico, Giovanna, Dander, Erica, Agnelli, Luca, Pruneri, Giancarlo, Donofrio, Gaetano, Bussolati, Ovidio, Giuliani, Nicola
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694402/
https://ncbi.nlm.nih.gov/pubmed/33167336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12113267
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