TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity

SIMPLE SUMMARY: We described the existence of an integrated Beclin 1, TLR9, and SIRT3 network involving autophagy, oxidative stress, and mitochondria that is essential for empagliflozin to protect against doxorubicin toxicity in the heart. Empagliflozin treatment increases the abundance of mitochond...

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Bibliografiske detaljer
Udgivet i:Biology (Basel)
Main Authors: Wang, Chao-Yung, Chen, Chun-Chi, Lin, Mei-Hsiu, Su, Hui-Ting, Ho, Ming-Yun, Yeh, Jih-Kai, Tsai, Ming-Lung, Hsieh, I-Chang, Wen, Ming-Shien
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693736/
https://ncbi.nlm.nih.gov/pubmed/33138323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology9110369
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