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OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions
8-oxoguanine DNA glycosylase (OGG1) is the main DNA glycosylase responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from duplex DNA to initiate base excision repair. This glycosylase activity is relevant in many pathological conditions including cancer, inflammation, and neurodegenerat...
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| 出版年: | Biomolecules |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7693665/ https://ncbi.nlm.nih.gov/pubmed/33114607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10111483 |
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