Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models

Hepatic metabolic stability is a key pharmacokinetic parameter in drug discovery. Metabolic stability is usually assessed in microsomal fractions and only the best compounds progress in the drug discovery process. A high-throughput single time point substrate depletion assay in rat liver microsomes...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Siramshetty, Vishal B., Shah, Pranav, Kerns, Edward, Nguyen, Kimloan, Yu, Kyeong Ri, Kabir, Md, Williams, Jordan, Neyra, Jorge, Southall, Noel, Nguyễn, Ðắc-Trung, Xu, Xin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693334/
https://ncbi.nlm.nih.gov/pubmed/33244000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77327-0
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