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Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models
Hepatic metabolic stability is a key pharmacokinetic parameter in drug discovery. Metabolic stability is usually assessed in microsomal fractions and only the best compounds progress in the drug discovery process. A high-throughput single time point substrate depletion assay in rat liver microsomes...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7693334/ https://ncbi.nlm.nih.gov/pubmed/33244000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77327-0 |
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