Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis

We have previously identified a shift from TNF-α-induced apoptosis to necroptosis that occurs under hyperglycemic conditions. This shift involves the downregulation or silencing of caspases and concurrent upregulation of necroptotic proteins leading to activation of the necrosome. In addition, under...

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Publicado en:Cell Death Discov
Main Authors: Deragon, Matthew A., McCaig, William D., Patel, Payal S., Haluska, Robert J., Hodges, Alexa L., Sosunov, Sergey A., Murphy, Michael P., Ten, Vadim S., LaRocca, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693268/
https://ncbi.nlm.nih.gov/pubmed/33298902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00370-3
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