Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis

We have previously identified a shift from TNF-α-induced apoptosis to necroptosis that occurs under hyperglycemic conditions. This shift involves the downregulation or silencing of caspases and concurrent upregulation of necroptotic proteins leading to activation of the necrosome. In addition, under...

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Publicat a:Cell Death Discov
Autors principals: Deragon, Matthew A., McCaig, William D., Patel, Payal S., Haluska, Robert J., Hodges, Alexa L., Sosunov, Sergey A., Murphy, Michael P., Ten, Vadim S., LaRocca, Timothy J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693268/
https://ncbi.nlm.nih.gov/pubmed/33298902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00370-3
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