Telomere Dysfunction Activates p53 and Represses HNF4α Expression Leading to Impaired Human Hepatocyte Development and Function

BACKGROUND AND AIMS: Telomere attrition is a major risk factor for end‐stage liver disease. Due to a lack of adequate models and intrinsic difficulties in studying telomerase in physiologically relevant cells, the molecular mechanisms responsible for liver disease in patients with telomere syndromes...

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Bibliographic Details
Published in:Hepatology
Main Authors: Munroe, Michael, Niero, Evandro Luis, Fok, Wilson Chun, Vessoni, Alexandre Teixeira, Jeong, Ho‐Chang, Brenner, Kirsten Ann, Batista, Luis Francisco Zirnberger
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693115/
https://ncbi.nlm.nih.gov/pubmed/32516515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31414
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