Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI. We examined a novel hypothesis: caspase 1 and caspase 11 serve as danger-associated molecular pattern (DAMPs) sensors in I...

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Udgivet i:Pathogens
Main Authors: Fagenson, Alexander M., Xu, Keman, Saaoud, Fatma, Nanayakkara, Gayani, Jhala, Nirag C., Liu, Lu, Drummer, Charles, Sun, Yu, Lau, Kwan N., Di Carlo, Antonio, Jiang, Xiaohua, Wang, Hong, Karhadkar, Sunil S., Yang, Xiaofeng
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7692674/
https://ncbi.nlm.nih.gov/pubmed/33114395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens9110879
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